Archive Pages Design$type=blogging

DNA of an Ancient Virus May Help Kill Modern Cancer

It’s time again for our regular “This could change everything!” moment where you decide if a recent discovery could change everything about...

>

It’s time again for our regular “This could change everything!” moment where you decide if a recent discovery could change everything about something, is merely interesting or is just another exaggerated claim. As is often the case, this story comes from the world of genome research. In fact, that’s the name of the journal where an article was published recently about a study of the DNA of ancient viruses that infected our ancestors but may now help save us from cancer. Will this indeed change everything about cancer?

“Dysregulated endogenous retroelements (EREs) are increasingly implicated in the initiation, progression, and immune surveillance of human cancer.”

“Dysregulated endogenous retroelements” would be a great name for a band made up of former PhD candidates in chemistry, but it’s the big-words name for fragments of DNA left behind in our genome by our ancestors – non-functioning pieces that don’t affect us now but may have helped early humans survive against killer viruses. Dr. George Kassiotis of the Retroviral Immunology Laboratory at the Francis Crick Institute in London led the team of researchers which combed through retroviral DNA, which comprises about 8 percent of the human genome, a much greater percentage than the 2 percent made up by known genes.

“In this study, we looked for viral DNA that is reactivated by cancer and produces products that the immune system can see. The hope is that if we can train the immune system to spot these, we can selectively target cancer cells.”

Dr. Kassitosis told Medical Xpress the purpose of the study in they took samples from cancer patients of 31 different cancer types using a technology called RNASeq, a leading-edge DNA sequencing process that reveals the presence and quantity of RNA in a biological sample at a given moment. Unfortunately, these RNA fragments are tiny and random so it can take up to 50 million “reads” per sample to build a complete picture of what happened when the viral DNA attacked the cancer cell. Dr. Kassitosis gives a great description of the degree of difficulty of this task:

“It’s been likened to trying to read a magazine that’s been shredded into millions of pieces, when you don’t even know what the magazine was supposed to be about or what language it’s in. All you have is random fragments, so to piece them together you need to see where they overlap.”

Nevertheless, they persisted – with the help of Crick’s in-house High Performance Computing cluster. The massive computer system helped the team narrow down this massive amount of shredded DNA magazine pieces to 130,000 different RNA transcripts, then to 6,000 transcripts that were specifically found in cancer samples, then to those transcripts that were melanoma-specific transcripts, then to 14 candidate transcripts that could produce unique cancer antigens, and finally to “nine unique peptides that could be visible to the immune system.” That’s an impressive computing task, but did it change everything? Some things? Anything?

“We hope this approach could form the basis of future cancer therapies, if we can vaccinate the immune system to recognize and attack cancer cells presenting these peptides.”

Let’s just say this discovery is definitely on the path to changing everything. Still, it’s exciting news that highlights the importance of dedication research using massive amounts of computer power for good … instead of for hacking into your credit card records.

COMMENTS

Loading...
Name

Âm Nhạc Ẩm Thực Angela Phương Trinh Angelina Jolie Bảo Thy benh-gan Bộ Ảnh - Video Brad Pitt Bùa Ngải Bước Nhảy Hoàn Vũ cac-benh-ve-gan Cao Thái Sơn Chi Pu Chuyện chỉ có ở Trung Quốc Chuyện kỳ lạ về trẻ em Chuyện Lạ Chuyện lạ bốn phương chọn lọc Chuyện lạ cảm động về các loài vật Chuyện lạ khó tin nhưng lại có thật Chuyện lạ ở Nhật Bản Chuyện lạ thế giới khó tin nhưng có thật Chuyện lạ về các loài vật Chuyện lạ về các tài năng hiếm có Chuyện lạ về chó và mèo Chuyện lạ về du lịch Chuyện lạ về hôn nhân - vợ chồng Chuyện lạ về những kỷ lục giảm cân Chuyện lạ về sữa Chuyện lạ Việt Nam có thật Cine Cộng Đồng Mạng Công Nghệ Cung Hoàng Đạo Cường Đô La Đàm Vĩnh Hưng Đàn Ông Đặng Thu Thảo dang-mieng Đĩa Bay Diễm My 9x Điện Ảnh Diệp Lâm Anh Đỗ Mạnh Cường Đời Sống doi-song Đông Nhi Đồng Tính Động Vật Du Lịch Đức Phúc fashion Gay Giảm cân Giáo Dục Giới Trẻ Hồ Ngọc Hà Hoa Hậu Hòa Minzy Hoài Linh Hoàng Thùy Linh Học Tiếng Anh hoc-duong Hot News HotNews Hương Giang Idol Hương Tràm Huỳnh Hiểu Minh Issac Jennifer Phạm Jessica Minh Anh Kenbi Khánh Phạm Khám Phá kham-pha Khánh Hiền Khmer News khoa-hoc khoa-hoc-cong-nghe Khoảnh Khắc Lan Khuê Lazada Lê Xuân Tiền Lều Phương Anh Linh Nga Lý Hải Mai Phương Thúy Maria Ozawa Mẹo Vặt Midu Minh Hằng Miu Lê Món ngon mỗi ngày Mọt Phim Musik Mỹ Linh Mỹ Tâm News Ngô Kiến Huy Ngọc Trinh Người ngoài hành tinh Nhật Kim Anh Những chuyện kỳ quặc trên thế giới Những hiện tượng bí ẩn và khó hiểu Những người có khả năng đặc biệt Noo Phước Thịnh Ốc Thanh Vân oto-xe-may Phạm Băng Băng Phạm Hương Phẫu Thuật Thẩm Mỹ Phong cách Phượng Channel Pokémon Go Quang Dũng Sao Shopping Sĩ Thanh Sơn Tùng M-TP sport Star Sức Khỏe suc-khoe suc-khoe-gioi-tinh Tâm Linh Tâm Sự Tăng Thanh Hà Taylor Swift Thanh Hằng Thành Lộc Thanh Thảo The Face - Gương mặt thương hiệu Thể Hình The Remix – Hòa Âm Ánh Sáng the-gioi Thời Trang Thu Minh Thu Phương Thượng Ẩn Thúy Nga Tin Nổi Bật Tin Nóng Tin Thế Giới Tin Trong Nước Tình Yêu Tom Cruise Trà Ngọc Hằng Trấn Thành Trường Giang Trương Nam Thành Tử Vi tv-show UFO Ung Thư Video Việt Hương Vietnam's Next Top Model Vĩnh Thụy Võ Cảnh Võ Hoàng Yến Vũ Khắc Tiệp Vũ Ngọc Anh Vũ Ngọc Đãng xa-hoi xe xo-gan Xu Hướng - Làm Đẹp
false
ltr
item
GIẢI TRÍ SAO 24H: DNA of an Ancient Virus May Help Kill Modern Cancer
DNA of an Ancient Virus May Help Kill Modern Cancer
https://mysteriousuniverse.org/wp-content/uploads/2019/09/dna-1903875_1280-643x440.jpg
GIẢI TRÍ SAO 24H
https://www.giaitrisao24h.com/2019/09/dna-of-ancient-virus-may-help-kill.html
https://www.giaitrisao24h.com/
https://www.giaitrisao24h.com/
https://www.giaitrisao24h.com/2019/09/dna-of-ancient-virus-may-help-kill.html
true
5412201294335186192
UTF-8
Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All BÀI CÙNG CHỦ ĐỀ LABEL ARCHIVE SEARCH Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago